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  1. UGENE
  2. UGENE-1374

MSA: add distance matrix options

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    Details

    • Type: Improvement
    • Status: Closed
    • Priority: Minor
    • Resolution: Won't Fix
    • Affects Version/s: 1.11.3
    • Fix Version/s: None
    • Component/s: Basic-MSA
    • Labels:
    • Affect Type:
      Userdefined

      Description

      Discussed in https://ugene.unipro.ru/tracker/browse/UGENE-1362

      The new options for the dialog could be:
      o ignore 5' terminal gaps
      o ignore 3' terminal gaps
      o ignore internal gaps
      o consecutive gaps as single difference (can't be selected if all previous "ignore" are marked)

      Examples:
      Consider a vs b from this multiple alignment (three sequences, so gaps present in both sequences are always ignored):
      a -> -AAAUGE-NEE
      b > --AEU-N-
      c > EAAAUGEONE

      *------------------
      x ignore 5' terminal gaps
      o ignore 3' terminal gaps
      o ignore internal gaps
      o consecutive gaps as single difference

      a -> AAUGENEE
      b > AEUN-
      (3/8)

      *------------------
      o ignore 5' terminal gaps
      x ignore 3' terminal gaps
      o ignore internal gaps
      o consecutive gaps as single difference

      a -> AAAUGEN
      b > -AEU-N
      (3/7)

      *------------------
      o ignore 5' terminal gaps
      o ignore 3' terminal gaps
      x ignore internal gaps
      o consecutive gaps as single difference

      a -> AAAUNEE
      b > -AEUN-
      (3/7)

      *------------------
      o ignore 5' terminal gaps
      o ignore 3' terminal gaps
      o ignore internal gaps
      x consecutive gaps as single difference

      a -> AAAUGENEE
      b > -AAUN-
      (4/7) (7 instead of 9 columns)

      Some combinations:

                                          • equivalent to option "--iddef 0" in UCLUST
                                            x ignore 5' terminal gaps
                                            x ignore 3' terminal gaps
                                            x ignore internal gaps
                                            o consecutive gaps as single difference

      a -> AAUN
      b -> AEUN
      (3/4)

                                          • equivalent to option "--iddef 1" in UCLUST (I would leave this "simple identity" as default.
                                            o ignore 5' terminal gap
                                            o ignore 3' terminal gaps
                                            o ignore internal gaps
                                            o consecutive gaps as single difference

      a -> AAAUGENEE
      b > -AEUN-
      (3/9)

                                          • equivalent to option "--iddef 2" in UCLUST
                                            x ignore 5' terminal gap
                                            x ignore 3' terminal gaps
                                            o ignore internal gaps
                                            o consecutive gaps as single difference

      a -> AAUGEN
      b > AEU-N
      (3/6)

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              Assignee:
              Unassigned
              Reporter:
              agu Agustín Ure
              Watchers:
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                Dates

                Created:
                Updated:
                Resolved: